产品名称
U17L2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/377630
Human Swissprot No.
Q6R6M4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6R6M4/entry
Mouse Swissprot No.
Q7M764
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7M764
免疫原
Synthesized peptide derived from human U17L2 AA range: 321-371
特异性
This antibody detects endogenous levels of U17L2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by OMIM, Mar 2008],
细胞定位
Nucleus . Endoplasmic reticulum .
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,caution:The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17. It is present with an interindividual variation in copy number and between 20 to 103 copies can be found both on chromosome 4 and chromosome 8.,caution:The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17. It is present with an interindividual variation in copy number and between 20 to 103 copies can be found in the genome both on chromosome 4 and chromosome 8.,function:Functions in cell apoptosis. Cleaves ubiquitin fusion protein substrates.,function:Functions in cell apoptosis. Cleaves ubiquitin fusion protein substrates. May also bind hyaluronan and RNA.,induction:Up-regulated by interleukin-4 and interleukin-6 (at protein level).,similarity:Belongs to the peptidase C19 family. USP17 subfamily.,tissue specificity:Broadly expressed.,tissue specificity:Expressed in heart, brain, liver and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
