产品名称
HSF4 Rabbit Polyclonal Antibody
蛋白名称
Heat shock factor protein 4 (HSF 4) (hHSF4) (Heat shock transcription factor 4) (HSTF 4)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9ULV5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ULV5/entry
Mouse Swissprot No.
Q9R0L1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R0L1
免疫原
Synthesized peptide derived from human protein . at AA range: 290-370
特异性
HSF4 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
heat shock transcription factor 4(HSF4) Homo sapiens Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008],
组织表达
Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues.
功能
disease:Defects in HSF4 are the cause of lamellar cataract [MIM:116800]; also known as Marner type cataract (CAM). Lamellar cataract is an autosomal dominant common type of infantile cataract. Finger malformation is observed in some kindreds.,function:DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.,PTM:Isoform HSF4B is constitutively sumoylated. Sumoylation represses the transcriptional activity and is promoted by phosphorylation on Ser-299. HSFA is not sumoylated.,PTM:Phosphorylated mainly on serine residues. Phosphorylation on Ser-299 promotes sumoylation on Lys-294.,similarity:Belongs to the HSF family.,subunit:Homotrimer. Exhibits constitutive DNA binding and forms trimers even in the absence of stress. Interacts with DUSP26, MAPK1, MAPK2 and MAP kinase p38.,tissue specificity:Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
