产品名称
PCD19 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/57526
Human Swissprot No.
Q8TAB3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TAB3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/279653
Mouse Swissprot No.
Q80TF3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80TF3
免疫原
Synthesized peptide derived from human PCD19 AA range: 841-891
特异性
This antibody detects endogenous levels of PCD19 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the delta-2 protocadherin subclass of the cadherin superfamily. The encoded protein is thought to be a calcium-dependent cell-adhesion protein that is primarily expressed in the brain. Defects in this gene are a cause of epilepsy female-restricted with mental retardation (EFMR). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010],
组织表达
Moderately expressed in all regions of the brain examined, with lowest levels found in the cerebellum. Moderate expression is also found in ovary, and low expression in all other tissues tested. Also detected in primary skin fibroblast.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
developmental stage:Expressed in developing cortical plate, amygdala and subcortical regions and in the ganglionic eminence.,disease:Defects in PCDH19 are the cause of epilepsy, female-restricted, with mental retardation (EFMR) [MIM:300088]; also known as convulsive disorder and mental retardation. EFMR is a condition characterized by seizure onset in infancy or early childhood and cognitive impairment. The disorder is sex-limited, with the phenotype being restricted to females. Males are apparently spared.,function:Potential calcium-dependent cell-adhesion protein.,similarity:Contains 6 cadherin domains.,tissue specificity:Moderately expressed in all regions of the brain examined, with lowest levels found in the cerebellum. Moderate expression is also found in ovary, and low expression in all other tissues tested. Also detected in primary skin fibroblast.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
