产品名称
AL1L1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10840
Human Swissprot No.
O75891
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75891/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/107747
Mouse Swissprot No.
Q8R0Y6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R0Y6
Rat Gene Link
https://www.uniprot.org/uniprot/64392
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P28037
免疫原
Synthesized peptide derived from human AL1L1 AA range: 512-562
特异性
This antibody detects endogenous levels of AL1L1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012],
组织表达
Highly expressed in liver, pancreas and kidney.
细胞定位
Cytoplasm, cytosol .
功能
catalytic activity:10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH.,similarity:Belongs to the aldehyde dehydrogenase family.,similarity:Contains 1 acyl carrier domain.,similarity:In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.,similarity:In the N-terminal section; belongs to the GART family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
