产品名称
RAB3A Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5864
Human Swissprot No.
P20336
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P20336/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19339
Mouse Swissprot No.
P63011
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P63011
Rat Gene Link
https://www.uniprot.org/uniprot/25531
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P63012
免疫原
Synthesized peptide derived from human RAB3A AA range: 27-77
特异性
This antibody detects endogenous levels of RAB3A at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
组织表达
Specifically expressed in brain.
细胞定位
Cytoplasm, cytosol . Lysosome . Cytoplasmic vesicle, secretory vesicle . Cell projection, axon . Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell junction, synapse, presynapse . Cell junction, synapse, postsynapse . Cycles between a vesicle-associated GTP-bound form and a cytosolic GDP-bound form. .
功能
function:Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.,similarity:Belongs to the small GTPase superfamily. Rab family.,subunit:Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3.,tissue specificity:Specifically expressed in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
