产品名称
PTF1A Rabbit Polyclonal Antibody
基因名称
PTF1A BHLHA29 PTF1P48
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/256297
Human Swissprot No.
Q7RTS3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7RTS3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19213
Mouse Swissprot No.
Q9QX98
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QX98
Rat Gene Link
https://www.uniprot.org/uniprot/117034
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q64305
免疫原
Synthesized peptide derived from human PTF1A AA range: 172-222
特异性
This antibody detects endogenous levels of PTF1A at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq, Jul 2008],
组织表达
Pancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers.
细胞定位
Nucleus . Cytoplasm . In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex (By similarity). .
功能
disease:Defects in PTF1A are the cause of diabetes mellitus and cerebellar hypoplasia/agenesis [MIM:609069].,function:Transcriptional activator. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays an important role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells (By similarity). Plays an important role in cerebellar development.,miscellaneous:An excellent marker of acinar cell differentiation in the pancreas.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subcellular location:In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex.,subunit:Component of the pancreas transcription factor 1 complex (PTF1) which is composed of TCF3/p75, TCF12/p64 and PTF1A/p48. TCF3 is responsible for the nuclear import of the p48/p64 complex. Interacts with TCF3 and RBPSUH/RBP-Jkappa.,tissue specificity:Pancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
