产品名称
EXOC4 Rabbit Polyclonal Antibody
基因名称
EXOC4 KIAA1699 SEC8 SEC8L1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/60412
Human Swissprot No.
Q96A65
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96A65/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20336
Mouse Swissprot No.
O35382
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35382
Rat Gene Link
https://www.uniprot.org/uniprot/116654
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q62824
免疫原
Synthesized peptide derived from human EXOC4 AA range: 512-562
特异性
This antibody detects endogenous levels of EXOC4 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
细胞定位
Midbody, Midbody ring . Cell projection . Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). Localizes at the leading edge of migrating cells (By similarity). .
功能
function:Component of the exocyst complex involved in the docking of exocystic vesicles with fusion sites on the plasma membrane.,similarity:Belongs to the SEC8 family.,subunit:The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
