产品名称
HMGB3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3149
Human Swissprot No.
O15347
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15347/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/15354
Mouse Swissprot No.
O54879
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O54879
免疫原
Synthesized peptide derived from human HMGB3 AA range: 123-173
特异性
This antibody detects endogenous levels of HMGB3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
组织表达
Expressed predominantly in placenta.
细胞定位
Nucleus . Chromosome . Cytoplasm .
功能
function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains.,tissue specificity:Expressed predominantly in placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
