产品名称
RECQ5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9400
Human Swissprot No.
O94762
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O94762/entry
免疫原
Synthesized peptide derived from human RECQ5 AA range: 647-697
特异性
This antibody detects endogenous levels of RECQ5 at Human
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],
细胞定位
[Isoform Beta]: Nucleus, nucleoplasm . Nucleus . Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks. Re-localizes from the nucleolus into the nucleus after replicative stress and significantly associates with WRN during S-phase (PubMed:23180761). .; [Isoform Alpha]: Cytoplasm .; [Isoform Gamma]: Cytoplasm .
功能
function:May have an important role in DNA metabolism.,similarity:Belongs to the helicase family. RecQ subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subunit:Interacts with TOP3A and TOP3B.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
