产品名称
PRI2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5558
Human Swissprot No.
P49643
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P49643/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19076
Mouse Swissprot No.
P33610
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P33610
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O89044
免疫原
Synthesized peptide derived from human PRI2 AA range: 369-419
特异性
This antibody detects endogenous levels of PRI2 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014],
细胞定位
nucleoplasm,alpha DNA polymerase:primase complex,primosome complex,
功能
function:DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.,similarity:Belongs to the eukaryotic-type primase large subunit family.,subunit:Heterodimer of a small subunit and a large subunit.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
