产品名称
CNST Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/163882
Human Swissprot No.
Q6PJW8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PJW8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/226744
Mouse Swissprot No.
Q8CBC4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CBC4
免疫原
Synthesized peptide derived from human CNST AA range: 296-346
特异性
This antibody detects endogenous levels of CNST at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010],
细胞定位
Cell membrane ; Single-pass membrane protein . Golgi apparatus, trans-Golgi network membrane ; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle . Located predominantly in the trans-Golgi network. Probably trafficks between the trans-Golgi network and the cell membrane via the secretory pathway.
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
