产品名称
STON2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/85439
Human Swissprot No.
Q8WXE9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8WXE9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/108800
Mouse Swissprot No.
Q8BZ60
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BZ60
免疫原
Synthesized peptide derived from human STON2 AA range: 47-97
特异性
This antibody detects endogenous levels of STON2 at Human/Mouse
稀释度
WB 1:500-2000; IF ICC 1:50-200;ELISA 1:2000-20000;IHC-p 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
细胞定位
Cytoplasm . Membrane . Cell junction, synapse, synaptosome . Some fraction is membrane-associated.
功能
domain:The Asn-Pro-Phe (NPF) motifs, which are found in proteins involved in the endocytic pathway, mediate the interaction with the EH domain of SYT1, SYT2, EPS15, EPS15R and ITSN1.,function:Adapter protein involved in endocytic machinery. May be involved in the vesicle recycling. May facilitate clathrin-coated vesicle uncoating.,similarity:Belongs to the Stoned B family.,similarity:Contains 1 MHD (mu homology) domain.,similarity:Contains 1 SHD (stonin homology) domain.,subcellular location:Some fraction is membrane-associated.,subunit:Interacts with the second C2 domain of synaptotagmins SYT1 and SYT2. Interacts with EPS15, EPS15R and ITSN1. Interacts indirectly with the AP-2 adapter complex.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
