产品名称
ENC1 Rabbit Polyclonal Antibody
基因名称
ENC1 KLHL37 NRPB PIG10
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8507
Human Swissprot No.
O14682
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O14682/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13803
Mouse Swissprot No.
O35709
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35709
免疫原
Synthesized peptide derived from human ENC1 AA range: 241-291
特异性
This antibody detects endogenous levels of ENC1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012],
组织表达
Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas. May be down-regulated in neuroblastoma tumors.
细胞定位
Nucleus matrix . Cytoplasm . Cytoplasm, cytoskeleton .
功能
developmental stage:Dramatically up-regulated upon neuronal differentiation.,function:Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. May be down-regulated in neuroblastoma tumors. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,induction:By TP53/p53.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated.,PTM:Ubiquitinated and probably targeted for proteasome-independent degradation.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,subunit:Binds to RB1. Hypophosphorylated RB1 associates with ENC1 during neuronal differentiation, while hyperphosphorylated RB1 associates with ENC1 in undifferentiating cells. Part of a complex that contains CUL3, RBX1 and ENC1.,tissue specificity:Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
