产品名称
BTBD9 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/114781
Human Swissprot No.
Q96Q07
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96Q07/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/224671
Mouse Swissprot No.
Q8C726
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C726
Rat Gene Link
https://www.uniprot.org/uniprot/294318
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5PQR3
免疫原
Synthesized peptide derived from human BTBD9 AA range: 424-474
特异性
This antibody detects endogenous levels of BTBD9 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome and may also be associated with Tourette Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011],
组织表达
Detected in the brain (at protein level) (PubMed:22658601). Moderately expressed in all specific brain regions examined (PubMed:11572484). Expressed in the dopaminergic neurons of the substantia nigra and A11 neurons (PubMed:22658601). Highly expressed in kidney and moderately expressed in all other adult and fetal tissues (PubMed:11572484).
细胞定位
cytoplasm,SCF ubiquitin ligase complex,
功能
disease:Genetic variations in BTBD9 are associated with susceptibility to restless legs syndrome type 6 (RLS6) [MIM:611185]; also called periodic limb movements in sleep. Restless legs syndrome (RLS) is a neurologic disorder characterized by an uncontrollable urge to move the legs during periods of rest. The majority of patients with RLS also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep.,similarity:Contains 1 BACK (BTB/Kelch associated) domain.,similarity:Contains 1 BTB (POZ) domain.,tissue specificity:Highly expressed in kidney and moderately expressed in all other adult and fetal tissues. Moderately expressed in all specific brain regions examined.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
