产品名称
MMS19 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/64210
Human Swissprot No.
Q96T76
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96T76/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/72199
Mouse Swissprot No.
Q9D071
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D071
免疫原
Synthesized peptide derived from human MMS19 AA range: 653-703
特异性
This antibody detects endogenous levels of MMS19 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
组织表达
Ubiquitously expressed with higher expression in testis.
细胞定位
Nucleus . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . In mitosis, enriched on centrosomes during prophase, localizes to the spindle during metaphase and surrounds compacted spindle midzone microtubules during telophase. .
功能
function:May play a role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription by interacting with ERCC2/XPD and ERCC3/XPB helicases, both subunits of NER-transcription factor TFIIH. May also function as a transcriptional coactivator of estrogen receptor (ER). May be involved in regulation of ER activity by bridging TFIIH with ER or may facilitate TFIIH-mediated phosphorylation of ER in specific promoters and cell types.,similarity:Belongs to the MET18/MMS19 family.,similarity:Contains 7 HEAT repeats.,subunit:Interacts with ERCC2/XPD, ERCC3/XPB and NCOA3/RAC3.,tissue specificity:Ubiquitously expressed with higher expression in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
