产品名称
POMT2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/29954
Human Swissprot No.
Q9UKY4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UKY4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/217734
Mouse Swissprot No.
Q8BGQ4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BGQ4
免疫原
Synthesized peptide derived from human POMT2 AA range: 177-227
特异性
This antibody detects endogenous levels of POMT2 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT1 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS).[provided by RefSeq, Oct 2008],
组织表达
Highly expressed in testis; detected at low levels in most tissues.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
catalytic activity:Dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.,cofactor:Magnesium. Manganese and calcium ions suppress enzyme activity.,disease:Defects in POMT2 are a cause of Walker-Warburg syndrome (WWS) [MIM:236670]; also known as hydrocephalus-agyria-retinal dysplasia or HARD syndrome. WWS is an autosomal recessive disorder characterized by cobblestone lissencephaly, hydrocephalus, agyria, retinal displasia, with or without encephalocele. It is often associated with congenital muscular dystrophy and usually lethal within the first few months of life.,function:Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,PTM:N-glycosylated.,similarity:Belongs to the glycosyltransferase 39 family.,similarity:Contains 3 MIR domains.,subunit:Interacts with POMT1.,tissue specificity:Highly expressed in testis; detected at low levels in most tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
