产品名称
VIP2 Rabbit Polyclonal Antibody
基因名称
PPIP5K2 HISPPD1 KIAA0433 VIP2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23262
Human Swissprot No.
O43314
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43314/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/227399
Mouse Swissprot No.
Q6ZQB6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6ZQB6
免疫原
Synthesized peptide derived from human VIP2 AA range: 266-316
特异性
This antibody detects endogenous levels of VIP2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the histidine acid phosphatase family of proteins. Despite containing a histidine acid phosphatase domain, the encoded protein functions as an inositol pyrophosphate kinase, and is thought to lack phosphatase activity. This kinase activity is the mechanism by which the encoded protein synthesizes high-energy inositol pyrophosphates, which act as signaling molecules that regulate cellular homeostasis and other processes. This gene may be associated with autism spectrum disorder in human patients. [provided by RefSeq, Sep 2016],
细胞定位
Cytoplasm, cytosol .
功能
catalytic activity:ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown).,catalytic activity:ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown).,catalytic activity:ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.,caution:Although related to histidine acid phosphatases, it lacks the conserved active sites, suggesting that it has no phosphatase activity.,function:Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP-InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2-InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer.,similarity:Belongs to the histidine acid phosphatase family. VIP1 subfamily.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
