产品名称
ZMAT3 Rabbit Polyclonal Antibody
蛋白名称
Zinc finger matrin-type protein 3 (Zinc finger protein WIG-1) (p53-activated gene 608 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9HA38
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HA38/entry
Mouse Swissprot No.
O54836
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54836
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O08781
免疫原
Synthesized peptide derived from human protein . at AA range: 210-290
特异性
ZMAT3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.
细胞定位
Nucleus . Nucleus, nucleolus .
功能
function:Acts as a bona fide target gene of p53. May play a role in the p53-dependent growth regulatory pathway. May contribute to p53-mediated apoptosis by regulation of p53 expression and translocation to the nucleus and nucleolus.,induction:By DNA damage in a p53-dependent manner. Up-regulated following ionizing radiation in primary squamous cell carcinoma of the lung and in various colon cancer cell lines.,similarity:Contains 3 matrin-type zinc fingers.,subunit:Interacts with dsRNA.,tissue specificity:Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
