产品名称
PSDE Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10213
Human Swissprot No.
O00487
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00487/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/59029
Mouse Swissprot No.
O35593
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35593
免疫原
Synthesized peptide derived from human PSDE AA range: 152-202
特异性
This antibody detects endogenous levels of PSDE at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012],
组织表达
Widely expressed. Highest levels in heart and skeletal muscle.
细胞定位
proteasome complex,nucleus,nucleoplasm,cytosol,proteasome regulatory particle, lid subcomplex,proteasome accessory complex,cytosolic proteasome complex,extracellular exosome,
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear.,similarity:Belongs to the peptidase M67A family. PSMD14 subfamily.,similarity:Contains 1 MPN (JAB/Mov34) domain.,subunit:Component of the 19S regulatory cap of the 26S proteasome.,tissue specificity:Widely expressed. Highest levels in heart and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
