产品名称
TYW2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55039
Human Swissprot No.
Q53H54
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q53H54/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/68260
Mouse Swissprot No.
Q8BG71
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BG71
Rat Gene Link
https://www.uniprot.org/uniprot/314999
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4V8B8
免疫原
Synthesized peptide derived from human TYW2 AA range: 11-61
特异性
This antibody detects endogenous levels of TYW2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008],
功能
function:Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.,pathway:tRNA modification; wybutosine-tRNA(Phe) biosynthesis.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 371.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the RNA methyltransferase trmD family. TYW2 subfamily.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
