产品名称
ARC1B Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10095
Human Swissprot No.
O15143
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15143/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/11867
Mouse Swissprot No.
Q9WV32
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WV32
Rat Gene Link
https://www.uniprot.org/uniprot/54227
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O88656
免疫原
Synthesized peptide derived from human ARC1B AA range: 27-77
特异性
This antibody detects endogenous levels of ARC1B at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011],
细胞定位
Cytoplasm, cytoskeleton . Nucleus .
功能
function:Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.,similarity:Belongs to the WD repeat ARPC1 family.,similarity:Contains 6 WD repeats.,subunit:Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
