产品名称
SMG9 Rabbit Polyclonal Antibody
蛋白名称
Protein SMG9 (Protein smg-9 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H0W8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H0W8/entry
Mouse Swissprot No.
Q9DB90
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DB90
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5PQS6
免疫原
Synthesized peptide derived from human protein . at AA range: 70-150
特异性
SMG9 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
SMG9, nonsense mediated mRNA decay factor(SMG9) Homo sapiens This gene encodes a regulatory subunit of the SMG1 complex, which plays a critical role in nonsense-mediated mRNA decay (NMD). Binding of the encoded protein to the SMG1 complex kinase scaffold protein results in the inhibition of its kinase activity. Mutations in this gene cause a multiple congenital anomaly syndrome in human patients, characterized by brain malformation, congenital heart disease and other features. [provided by RefSeq, Jul 2016],
组织表达
Brain,Epithelium,Muscle,Teratocarcinoma,
细胞定位
intracellular,cytosol,
功能
function:Component of the SMG1C complex, a mRNA surveillance complex that recognizes and degrades mRNAs containing premature translation termination codons (PTCs) via the nonsense-mediated mRNA decay (NMD). The complex probably acts by associating with ribosomes during tranlation termination on mRNPs. If an exon junction complex (EJC) is located 50-55 or more nucleotides downstream from the termination codon, smg1 phosphorylates upf1/rent1, triggering nonsense-mediated mRNA decay (NMD). In the SMG1C complex, it is required for the efficient association between smg1 and smg8.,PTM:Phosphorylated by SMG1.,similarity:Belongs to the SMG9 family.,subunit:Component of the SMG1C complex, at least composed of SMG1, SMG8 and SMG9. The SMG1C complex is then recruited on premature translation termination codons (PTCs) to form the ribosome:SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
