产品名称
MPDZ Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8777
Human Swissprot No.
O75970
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75970/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/17475
Mouse Swissprot No.
Q8VBX6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VBX6
Rat Gene Link
https://www.uniprot.org/uniprot/29365
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O55164
免疫原
Synthesized peptide derived from human MPDZ AA range: 1564-1614
特异性
This antibody detects endogenous levels of MPDZ at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015],
组织表达
Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
细胞定位
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells (By similarity). Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. .
功能
similarity:Contains 13 PDZ (DHR) domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
