产品名称
EAF6 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/64769
Human Swissprot No.
Q9HAF1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HAF1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/70088
Mouse Swissprot No.
Q2VPQ9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q2VPQ9
免疫原
Synthesized peptide derived from human EAF6 AA range: 94-144
特异性
This antibody detects endogenous levels of EAF6 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
细胞定位
Nucleus, nucleolus . Chromosome, centromere, kinetochore .
功能
function:Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the EAF6 family.,subunit:Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit HTATIP and the subunits EP400, TRRAP, BRD8, EPC1, DMAP1, RUVBL1, RUVBL2, ING3, actin, ACTL6A, MORF4L1, MORF4L2, MRGBP, YEATS4, VPS72 and EAF6. Component of the HBO1 complex composed at least of ING4 or ING5, MYTS2/HBO1, EAF6, and one of PHF15, PHF16 and PHF17.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
