产品名称
QPCT Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/25797
Human Swissprot No.
Q16769
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q16769/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/70536
Mouse Swissprot No.
Q9CYK2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CYK2
免疫原
Synthesized peptide derived from human QPCT AA range: 233-283
特异性
This antibody detects endogenous levels of QPCT at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008],
功能
catalytic activity:L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).,cofactor:Binds 1 zinc ion per subunit.,function:Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.,similarity:Belongs to the glutaminyl-peptide cyclotransferase family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
