产品名称
ZMIZ2 Rabbit Polyclonal Antibody
基因名称
ZMIZ2 KIAA1886 ZIMP7 HRIHFB2007
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/83637
Human Swissprot No.
Q8NF64
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NF64/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/52915
Mouse Swissprot No.
Q8CIE2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CIE2
免疫原
Synthesized peptide derived from human ZMIZ2 AA range: 512-562
特异性
This antibody detects endogenous levels of ZMIZ2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010],
组织表达
Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.
细胞定位
Nucleus . Detected at replication foci throughout S phase.
功能
domain:The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.,function:Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.,similarity:Contains 1 SP-RING-type zinc finger.,subcellular location:Detected at replication foci throughout S phase.,subunit:Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription.,tissue specificity:Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
