产品名称
SCOT1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5019
Human Swissprot No.
P55809
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P55809/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67041
Mouse Swissprot No.
Q9D0K2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D0K2
Rat Gene Link
https://www.uniprot.org/uniprot/690163
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/B2GV06
免疫原
Synthesized peptide derived from human SCOT1 AA range: 105-155
特异性
This antibody detects endogenous levels of SCOT1 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008],
组织表达
Abundant in heart, followed in order by brain, kidney, skeletal muscle, and lung, whereas in liver it is undetectable. Expressed (at protein level) in all tissues (except in liver), most abundant in myocardium, then brain, kidney, adrenal glands, skeletal muscle and lung; also detectable in leukocytes and fibroblasts.
功能
catalytic activity:Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.,disease:Defects in OXCT1 are a cause of ketoacidosis [MIM:245050].,function:Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.,pathway:Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.,similarity:Belongs to the 3-oxoacid CoA-transferase family.,subunit:Homodimer.,tissue specificity:Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
