产品名称
HDBP1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/338328
Human Swissprot No.
Q8IV16
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IV16/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/68453
Mouse Swissprot No.
Q9D1N2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D1N2
免疫原
Synthesized peptide derived from human HDBP1 AA range: 1-51
特异性
This antibody detects endogenous levels of HDBP1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014],
细胞定位
Apical cell membrane ; Lipid-anchor, GPI-anchor . Basolateral cell membrane ; Lipid-anchor, GPI-anchor . Cell membrane ; Lipid-anchor, GPI-anchor .
功能
caution:The mouse ortholog has been suggested to be a GPI-anchored protein, but no GPI-anchor is detected by prediction methods.,function:Plays a key role in the lipolytic processing of chylomicrons.,polymorphism:The missense variant Arg-56 may be associated with severe hypertriglyceridemia and chylomicronemia.,similarity:Contains 1 UPAR/Ly6 domain.,subcellular location:Localized at the cell surface.,subunit:Binds with high affinity to high-density lipoprotein (HDL) (By similarity). Binds to lipoprotein lipase (LPL), chylomicrons and APOA5.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
