产品名称
TPC1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/53373
Human Swissprot No.
Q9ULQ1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ULQ1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/252972
Mouse Swissprot No.
Q9EQJ0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EQJ0
Rat Gene Link
https://www.uniprot.org/uniprot/246215
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WTN5
免疫原
Synthesized peptide derived from human TPC1 AA range: 104-154
特异性
This antibody detects endogenous levels of TPC1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008],
组织表达
Highest expression found in the heart and kidney, and lowest expression found in the spleen.
细胞定位
Lysosome membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein .
功能
domain:Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.,function:May function as one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane.,similarity:Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.,subunit:Dimer .,tissue specificity:Highest expression found in the heart and kidney, and lowest expression found in the spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
