产品名称
H17B6 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8630
Human Swissprot No.
O14756
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O14756/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/27400
Mouse Swissprot No.
Q9R092
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R092
Rat Gene Link
https://www.uniprot.org/uniprot/286964
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O54753
免疫原
Synthesized peptide derived from human H17B6 AA range: 28-78
特异性
This antibody detects endogenous levels of H17B6 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013],
组织表达
Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.
细胞定位
Microsome membrane ; Peripheral membrane protein ; Lumenal side . Early endosome membrane ; Peripheral membrane protein ; Lumenal side .
功能
catalytic activity:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.,catalytic activity:Retinol + NAD(+) = retinal + NADH.,catalytic activity:Testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH.,function:NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,tissue specificity:Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
