产品名称
TULP3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7289
Human Swissprot No.
O75386
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75386/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22158
Mouse Swissprot No.
O88413
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88413
免疫原
Synthesized peptide derived from human TULP3 AA range: 257-307
特异性
This antibody detects endogenous levels of TULP3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009],
组织表达
Expressed at high levels in testis, ovaries, thyroid, and spinal chord.
细胞定位
Nucleus. Cell membrane. Cell projection, cilium . Cytoplasm . Secreted . Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. .
功能
similarity:Belongs to the TUB family.,tissue specificity:Expressed at high levels in testis, ovaries, thyroid, and spinal chord.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
