产品名称
SPTN2 Rabbit Polyclonal Antibody
基因名称
SPTBN2 KIAA0302 SCA5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6712
Human Swissprot No.
O15020
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15020/entry
Rat Gene Link
https://www.uniprot.org/uniprot/29211
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QWN8
免疫原
Synthesized peptide derived from human SPTN2 AA range: 644-694
特异性
This antibody detects endogenous levels of SPTN2 at Human/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009],
组织表达
Highly expressed in brain, kidney, pancreas, and liver, and at lower levels in lung and placenta.
细胞定位
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
功能
disease:Defects in SPTBN2 are the cause of spinocerebellar ataxia type 5 (SCA5) [MIM:600224]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA5 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder with variable age at onset, ranging between 10 and 50 years.,function:Probably plays an important role in neuronal membrane skeleton.,similarity:Belongs to the spectrin family.,similarity:Contains 1 PH domain.,similarity:Contains 17 spectrin repeats.,similarity:Contains 2 CH (calponin-homology) domains.,tissue specificity:Highly expressed in brain, kidney, pancreas, and liver, and at lower levels in lung and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
