产品名称
SESN3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/143686
Human Swissprot No.
P58005
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P58005/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/75747
Mouse Swissprot No.
Q9CYP7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CYP7
免疫原
Synthesized peptide derived from human SESN3 AA range: 35-85
特异性
This antibody detects endogenous levels of SESN3 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012],
功能
caution:Positions 27 to 191 are in EST BF328700; positions 244 to 492 can be found in EST BG291497 but several frameshifts need to be corrected to restore the correct sequence. Positions 412 to 492 are in AF086251 with no conflicts.,similarity:Belongs to the sestrin family.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
