产品名称
NMRL1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/57407
Human Swissprot No.
Q9HBL8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HBL8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67824
Mouse Swissprot No.
Q8K2T1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K2T1
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P86172
免疫原
Synthesized peptide derived from human NMRL1 AA range: 179-229
特异性
This antibody detects endogenous levels of NMRL1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015],
细胞定位
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.
功能
similarity:Belongs to the NmrA-type oxidoreductase family.,subunit:Homodimer; disulfide-linked.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
