产品名称
DBC1 Rabbit Polyclonal Antibody
基因名称
DBC1 DBCCR1 FAM5A IB3089A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1620
Human Swissprot No.
O60477
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60477/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56710
Mouse Swissprot No.
Q920P3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q920P3
Rat Gene Link
https://www.uniprot.org/uniprot/140610
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q925T8
免疫原
Synthesized peptide derived from human DBC1 AA range: 100-150
特异性
This antibody detects endogenous levels of DBC1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.
功能
function:Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.,miscellaneous:DBC1 is silenced by methylation in 50% of bladder cancer cell lines.,similarity:Belongs to the FAM5 family.,similarity:Contains 1 MACPF domain.,tissue specificity:Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
