产品名称
NLRC4 Rabbit Polyclonal Antibody
基因名称
NLRC4 CARD12 CLAN CLAN1 IPAF UNQ6189/PRO20215
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/58484
Human Swissprot No.
Q9NPP4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NPP4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/268973
Mouse Swissprot No.
Q3UP24
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UP24
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/F1M649
免疫原
Synthesized peptide derived from human NLRC4 AA range: 481-531
特异性
This antibody detects endogenous levels of NLRC4 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014],
组织表达
Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.
细胞定位
Cytoplasm . Cytoplasm, cytosol . Inflammasome .
功能
function:Plays a role in the promotion of apoptosis.,similarity:Contains 1 CARD domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 14 LRR (leucine-rich) repeats.,subcellular location:Cytoplasmic filaments.,subunit:Self-associates and binds to ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction.,tissue specificity:Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
