产品名称
MPZL2 Rabbit Polyclonal Antibody
基因名称
MPZL2 EVA EVA1 UNQ606/PRO1192
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10205
Human Swissprot No.
O60487
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60487/entry
Mouse Swissprot No.
O70255
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O70255
免疫原
Synthesized peptide derived from human MPZL2 AA range: 144-194
特异性
This antibody detects endogenous levels of MPZL2 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed. In fetal tissues, highest expression in the inner ear. In adult tissues, highest levels in thymus and lung.
细胞定位
Membrane ; Single-pass type I membrane protein .
功能
function:Mediates homophilic cell-cell adhesion.,similarity:Belongs to the myelin P0 protein family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,tissue specificity:Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
