产品名称
HERC3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8916
Human Swissprot No.
Q15034
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q15034/entry
免疫原
Synthesized peptide derived from human HERC3 AA range: 985-1035
特异性
This antibody detects endogenous levels of HERC3 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012],
细胞定位
Cytoplasm. Cytoplasmic vesicle. Also found in vesicular-like structures.
功能
function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,PTM:Ubiquitinated; which promotes degradation by the proteasome.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 7 RCC1 repeats.,subcellular location:Also found in vesicular-like structures.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
