产品名称
PCSK5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5125
Human Swissprot No.
Q92824
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92824/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/18552
Mouse Swissprot No.
Q04592
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q04592
Rat Gene Link
https://www.uniprot.org/uniprot/116548
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P41413
免疫原
Synthesized peptide derived from human PCSK5 AA range: 1507-1557
特异性
This antibody detects endogenous levels of PCSK5 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014],
组织表达
Expressed in T-lymphocytes.
细胞定位
[Isoform PC6A]: Secreted. Secreted through the regulated secretory pathway. .; [Isoform PC6B]: Endomembrane system; Single-pass type I membrane protein. Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes. .
功能
alternative products:2 isoforms may be produced,catalytic activity:Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.,domain:The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.,function:Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif.,similarity:Belongs to the peptidase S8 family.,similarity:Contains 1 homo B/P domain.,similarity:Contains 1 PLAC domain.,tissue specificity:Expressed in T-lymphocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
