产品名称
CEL3B Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23436
Human Swissprot No.
P08861
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P08861/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67868
Mouse Swissprot No.
Q9CQ52
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CQ52
免疫原
Synthesized peptide derived from human CEL3B AA range: 206-256
特异性
This antibody detects endogenous levels of CEL3B at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009],
组织表达
Pancreas. Not detectable in keratinocytes.
细胞定位
extracellular space,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
