产品名称
ROP1A Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54763
Human Swissprot No.
Q9HAT0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HAT0/entry
免疫原
Synthesized peptide derived from human ROP1A AA range: 85-135
特异性
This antibody detects endogenous levels of ROP1A at Human
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015],
组织表达
Testis specific in adult. Overexpressed in hematologic tumor cells.
细胞定位
Cell projection, cilium, flagellum . In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath. .
功能
developmental stage:Expressed in fetal liver.,domain:The RIIa domain mediates interaction with AKAP3.,miscellaneous:The name 'ropporin' comes from the Japanese word 'oppo' which means 'tail'.,similarity:Belongs to the ropporin family.,similarity:Contains 1 RIIa domain.,subcellular location:In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath.,subunit:Homodimer. Interacts with AKAP3 and RHPN1 (By similarity). May interact with SPA17.,tissue specificity:Testis specific in adult. Overexpressed in hematologic tumor cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
