产品名称
S27A1 Rabbit Polyclonal Antibody
基因名称
SLC27A1 ACSVL5 FATP1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/376497
Human Swissprot No.
Q6PCB7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PCB7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/26457
Mouse Swissprot No.
Q60714
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60714
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P97849
免疫原
Synthesized peptide derived from human S27A1 AA range: 115-165
特异性
This antibody detects endogenous levels of S27A1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
组织表达
Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. Expressed in brain gray matter (PubMed:21395585).
细胞定位
Cell membrane ; Single-pass membrane protein . Endomembrane system ; Single-pass membrane protein . Cytoplasm . Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake. Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1. Predominantly cytoplasmic in myocytes. .
功能
function:Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of Fatp1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids.,miscellaneous:FATP1-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity.,similarity:Belongs to the ATP-dependent AMP-binding enzyme family.,subcellular location:Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes.,subunit:Self-associates. May function as an homodimer.,tissue specificity:Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
