产品名称
NEO1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4756
Human Swissprot No.
Q92859
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92859/entry
Mouse Swissprot No.
P97798
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P97798
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P97603
免疫原
Synthesized peptide derived from human NEO1 AA range: 82-132
特异性
This antibody detects endogenous levels of NEO1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],
组织表达
Widely expressed and also in cancer cell lines.
细胞定位
Cell membrane; Single-pass type I membrane protein.
功能
alternative products:Additional isoforms seem to exist,function:May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.,similarity:Belongs to the immunoglobulin superfamily. DCC family.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 6 fibronectin type-III domains.,tissue specificity:Widely expressed and also in cancer cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
