产品名称
LPP1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8611
Human Swissprot No.
O14494
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O14494/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19012
Mouse Swissprot No.
Q61469
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61469
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O08564
免疫原
Synthesized peptide derived from human LPP1 AA range: 219-269
特异性
This antibody detects endogenous levels of LPP1 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013],
组织表达
Widely expressed with highest expression found in prostate (PubMed:9305923). Found to be down-regulated in colon adenocarcinomas (PubMed:9570154). ; [Isoform 1]: Predominant in kidney, lung, placenta and liver. ; [Isoform 2]: Predominant in heart and pancreas.
细胞定位
Cell membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein . Membrane raft ; Multi-pass membrane protein . Membrane, caveola ; Multi-pass membrane protein .
功能
alternative products:Additional isoforms seem to exist,catalytic activity:A 3-sn-phosphatidate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.,caution:PubMed:9305923 states that this phosphatase does not hydrolyze sphingosine 1-phosphate while PubMed:9705349 states that it does.,enzyme regulation:Inhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment.,function:Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.,induction:By androgens.,PTM:N-glycosylated. Contains high-mannose oligosaccharides.,similarity:Belongs to the PA-phosphatase related phosphoesterase family.,subunit:Homodimer.,tissue specificity:Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver; isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
