产品名称
CNIH2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/254263
Human Swissprot No.
Q6PI25
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PI25/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12794
Mouse Swissprot No.
O35089
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35089
Rat Gene Link
https://www.uniprot.org/uniprot/361705
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5BJU5
免疫原
Synthesized peptide derived from human CNIH2 AA range: 10-60
特异性
This antibody detects endogenous levels of CNIH2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
组织表达
Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic density . Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). .
功能
function:Involved in the transport and maturation of proteins.,similarity:Belongs to the cornichon family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
