产品名称
EMAL4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/27436
Human Swissprot No.
Q9HC35
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HC35/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/78798
Mouse Swissprot No.
Q3UMY5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UMY5
免疫原
Synthesized peptide derived from human EMAL4 AA range: 398-448
特异性
This antibody detects endogenous levels of EMAL4 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015],
细胞定位
Cytoplasm, cytoskeleton . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, microtubule organizing center . Midbody . Localizes to microtubules (MTs) during interphase with a significantly reduced affinity for MTs during mitosis. .
功能
developmental stage:Strongly overexpressed during mitosis.,function:May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.,similarity:Belongs to the WD repeat EMAP family.,similarity:Contains 9 WD repeats.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
