产品名称
ZMYM3 Rabbit Polyclonal Antibody
基因名称
ZMYM3 DXS6673E KIAA0385 ZNF261
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9203
Human Swissprot No.
Q14202
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14202/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56364
Mouse Swissprot No.
Q9JLM4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JLM4
免疫原
Synthesized peptide derived from human ZMYM3 AA range: 258-308
特异性
This antibody detects endogenous levels of ZMYM3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked mental retardation. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2010],
组织表达
Most abundant in brain, moderate in muscle and heart, low in other tissues except placenta.
功能
disease:A chromosomal aberration involving ZMYM3 may be a cause of X-linked mental retardation in Xq13.1. Translocation t(X;13)(q13.1;?).,similarity:Contains 9 MYM-type zinc fingers.,subunit:May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.,tissue specificity:Most abundant in brain, moderate in muscle and heart, low in other tissues except placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
