产品名称
LMTK1 Rabbit Polyclonal Antibody
基因名称
AATK AATYK KIAA0641 LMR1 LMTK1
蛋白名称
Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q6ZMQ8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6ZMQ8/entry
Mouse Swissprot No.
Q80YE4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80YE4
免疫原
Synthesized peptide derived from human protein . at AA range: 1110-1190
特异性
LMTK1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011],
细胞定位
Membrane ; Single-pass type I membrane protein . Cytoplasm . Cytoplasm, perinuclear region . Predominantly perinuclear.
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:May be involved in neuronal differentiation.,induction:Up-regulated during apoptosis.,PTM:Autophosphorylated. Phosphorylated by CDK5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Predominantly perinuclear.,subunit:Interacts with CDK5.,tissue specificity:Expressed in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
