产品名称
TCEA1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6917
Human Swissprot No.
P23193
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P23193/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/21399
Mouse Swissprot No.
P10711
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P10711
Rat Gene Link
https://www.uniprot.org/uniprot/362479
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4KLL0
免疫原
Synthesized peptide derived from human TCEA1 AA range: 50-100
特异性
This antibody detects endogenous levels of TCEA1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
功能
alternative products:Additional isoforms seem to exist,disease:A chromosomal rearrangement involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.,function:Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.,miscellaneous:S-II binds to RNA-polymerase II in the absence of transcription.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TFS-II family.,similarity:Contains 1 TFIIS central domain.,similarity:Contains 1 TFIIS N-terminal domain.,similarity:Contains 1 TFIIS-type zinc finger.,subunit:Interacts with EAF2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
