产品名称
ZFYV1 Rabbit Polyclonal Antibody
基因名称
ZFYVE1 DFCP1 KIAA1589 TAFF1 ZNFN2A1 PP10436
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/53349
Human Swissprot No.
Q9HBF4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HBF4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/217695
Mouse Swissprot No.
Q810J8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q810J8
免疫原
Synthesized peptide derived from human ZFYV1 AA range: 318-368
特异性
This antibody detects endogenous levels of ZFYV1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
组织表达
[Isoform 2]: Highly expressed in heart. Also detected in the testis. ; [Isoform 1]: Expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Highly expressed in heart.
细胞定位
Golgi apparatus, Golgi stack . Golgi apparatus . Endoplasmic reticulum . Lipid droplet . Preautophagosomal structure . Mitochondrion . Resides predominantly in the cisternal stacks of the Golgi (PubMed:11256955). Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (PubMed:22178386). During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (PubMed:31293035, PubMed:25876663). Localizes to lipid droplets in the presence of oleic acid (PubMed:31293035, PubMed:30970241). .
功能
sequence caution:Translated as Trp.,similarity:Contains 2 FYVE-type zinc fingers.,subcellular location:Resides predominantly in the cisternal stacks of the Golgi.,subunit:Binds to phosphatidylinositol-3-phosphate (PtdIns3P) through its FYVE-type zinc finger.,tissue specificity:Isoform 1 was expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Both isoforms, 1 and 2 showed a high expression in heart. Isoform 2 is also detected in the testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
